UNIVERSITAS AIRLANGGA



Detail Article

Jurnal THT - KL

ISSN 23378417

Vol. 10 / No. 1 / Published : 2017-01

Order : 1, and page :1 - 10

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Original Article :

Decrease of haemoglobin, neutrophil, and platelet level following cisplatin-paclitaxel chemotherapy on head and neck malignancy (a research)

Author :

  1. Iskandar Zulkarnain*1
  2. Bakti Surarso*2
  3. Nyilo Purnami*3
  1. Mahasiswa Fakultas Kedokteran
  2. Dosen Fakultas Kedokteran
  3. Dosen Fakultas Kedokteran

Abstract :

Background: Cisplatin-paclitaxel is one of common chemotherapy regimen that has been used in head and neck cancer. One of the main side effect of cisplatin-paclitaxel is decrease of hematopoietic cells. This condition could cause decrease of hemoglobin (Hb), neutrophil and platelet. The purpose of this study is to prove the decrease of Hb, neutrophil and platelet post cisplatin-paclitaxel chemotherapy in head and neck cancer patients at ORL-HNS Teratai surgery ward of Dr. Soetomo hospital. Method: All head and neck cancer patients in ORL-HNS oncology OPD who got cisplatin-paclitaxel chemotherapy in ORL-HNS Teratai Surgery Ward, that met inclusion and exlusion criterias were selected by consecutive sampling and examined for Hb level, neutrophil count and platelet count pre and post chemotherapy. The results were analyzed statistically by paired t2 samples test. Result: there were33 patients, 23 male and 10 female with comparison 2,3 : 1. There was significant difference of Hb level (p=0.000), neutrophil count (p=0.000) and platelet count (p=0.000) postcisplatin-paclitaxel chemotherapy. Percentage of decreased Hb level was 10.61%, decreased neutrophil count was 38.06%and decreasedplatelet count was 13.21%. Conclusion: The study concluded that there weredecrease of Hb, neutrophil and platelet post cisplatin-paclitaxel chemotherapy in head and neck malignant tumor patients at ORL-HNS Teratai surgery ward of Dr. Soetomo General Hospital.

Keyword :

head and neck cancer, cisplatin-paclitaxel, hematopoietic cells (Hb, neutrophil and platelet),


References :

Ridge JA, Glisson BS, Lango MN,(2008) Head and neck tumors. In (Pazdur R, Wagman LD, Camphausen KA, Hoskins WJ, eds). Cancer management: a multidisciplinary approach pp. 43-90 : Manhasset : CMP Healthcare Media

Hemati S, Jolfaie NA, Abbas Gookizadeh, Rafenia M, Ghavamnasin R,(2012) The effects of vitamin E and selenium on cisplatin-induced nephrotoxicity in cancer patients treated with cisplatin-based chemotherapy: A randomized, pacebo-controlled study 18(7): 626-7 : Journal of Research in Medical Sciences

Aminullah Y, Wiratno, Susilangingsih N,(2012) Pengaruh kombinasi vitamin C dan E dosis tinggi terhadap sistem hemopoetik penderita kanker kepala dan leher yang mendapat kemoterapi cisplatin. 1(2): 89-94 : Medica Hospitalia

Rabah SO,(2010) Acute taxol nephrotoxicity: histological and ultrastructural studies of mice kidney parenchyma 17: 105-14 : Saudi Journal of Biological Sciences

Rasjidi I,(2011) Kemoterapi. Dalam (Nugroho AW, ed). Buku ajar onkologi klini



Archive Article

Cover Media Content

Volume : 10 / No. : 1 / Pub. : 2017-01
  1. Decrease Of Haemoglobin, Neutrophil, And Platelet Level Following Cisplatin-paclitaxel Chemotherapy On Head And Neck Malignancy (a Research)
  2. Management Of Tracheal Stenosis Using Tracheofissure Technique And T-tube Silicone Insertion
  3. Removal Of Wire Foreign Body On Hipopharynx (a Case Report)
  4. The Role Of Tranforming Growth Factor Beta (tgf-β) On Rhinitis Allergy
  5. The Role Of Cytokine On Otitis Media With Effusion

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