UNIVERSITAS AIRLANGGA



Detail Article

Jurnal Penelitian Medika Eksakta

ISSN 1411-6626

Vol. 5 / No. 2 / Published : 2004-08

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Original Article :

The potency of morinda citrifolia extract as hepatopro- tective in mice

Author :

  1. Widayat Sastrowardoyo*1
  2. Sri Agus Sudjarwo*2
  1. Pusat Penelitian Obat Tradisional, Lembaga Penelitian Universitas Airlangga
  2. Pusat Penelitian Obat Tradisional, Lembaga Penelitian Universitas Airlangga

Abstract :

The hepatoprotective effect of Morinda citrifolia extract was investigated against paracetamol induced hepatic damage. Paracetamol at a dose of 400 mg/kg body weight produced liver damage in mice as manifested by the risemin serum level of Glutamate Oxaloacetate Transaminase (SGOT) and Glutamate Pyruvate Transaminase (SGPT) to 133.3  5.31 /L and 74.9  6.54 /L respectively, compared to respective control values of 76.3  9.18 /L and 35.2  4.57 /L.Pretreatment with Morinda citrifolia extract at dose 400 mg/kg BW but not at dose 100 mg/kg BW and dose 200 mg, significantly prevent paracetamol induced rise in SGOT and SGPT. Morinda citrifolia at dose 100/kg BW, 200 mg/kg BW and 400 mg BW inhibited rise SGOT was 130.7  8.37, 127.5  7.84 and 114  6.79 /L respectively and SGPT was 78.6  5.42, 66.9  9.78 and 59.3  9.76 /L respectivelyThe result suggest that the Morinda citrifolia extract possesses hepatoprotective activity is probably connected with its antioxidant activity

Keyword :

Morinda citrifolia, hepatoprotective,


References :





Archive Article

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Volume : 5 / No. : 2 / Pub. : 2004-08
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  2. Cytotoxicity of the rapied heat cured acrylic resin after water storage
  3. Modification of water flow rate in tubifex sp culture to increase quality ornament fish
  4. Iodium and protein content in canned meat complemented with sea weed (eucheuma cottonii)
  5. Use of internal reflection method for measurement of biological tissues measurement
  6. Risk difference of hypertension occurrence based on smoking pattern
  7. The potency of morinda citrifolia extract as hepatopro- tective in mice
  8. Mother’s perception toward healthy claim and suplement beneficiary on relation with suplement (vitamin, mineral and apetizer) consumption in below 5 yrs children
  9. The evaluation of metal ceramic work in dental laboratory of pstkg – fkg unair, 1999–2003
  10. Isolation and determination endophytic fungi from aglaia elliptica, aglaia eusideroxylon, aglaia odorata dan aglaia odoratissima

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