Berkala Ilmiah Kimia Farmasi
ISSN 2302-8270
Vol. 2 / No. 1 / Published : 2013-06
Order : 2, and page :9 - 15
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Original Article :
Validasi metode kromatografi gas-spektrometri massa untuk penetapan kadar residu endosulfan dalam kubis
Author :
- Dini Tri Anggraini*1
- Riesta Primaharinastiti*2
- Isnaeni*3
- Mahasiswa Fakultas Farmasi
- Dosen Fakultas Farmasi
- Dosen Fakultas Farmasi
Abstract :
The purpose of this study is to develop and validate a simple method suitable for analysis of trace amounts of endosulfan in cabbage. Cabbage samples were extracted with acetone and endosulfan was partitioned into dichloromethane/n-hexane (1:1, v/v). Final determination was performed by gas chromatography with mass spectrometry. Recovery studies were performed at 0.02 mg/kg fortification level of each compound (endosulfan I, endosulfan II, endosulfan sulfat) and the recoveries obtained ranged 69.67% to 124.02% with coefficient of variation values of 5.56-11.54%. The method showed good linearity over the range assayed 2-6 µg/mL and the detection and quantification limits for endosulfan studied varied, 0.1273 µg/mL to 0.1469 µg/mL and 0.856 µg/mL to 0.4451 µg/mL respectively.
Keyword :
GC-MS, , endosulfan, pesticides, validation, cabbage,
References :
Bempah, C.K., Buah-Kwofie, A., Enimil, E., and Blewu, B. ,(2011) Residues of organochlorine pesticides in vegetables marketed in Greater Accra region of Ghana Journal : Food Control, (25)
