PharmaScientia
ISSN 2302-0725
Vol. 1 / No. 2 / Published : 2012-12
Order : 3, and page :12 - 20
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Original Article :
Karakterisasi sediaan dan uji pelepasan natrium diklofenak dengan sistem mikroemulsi dalam basis gel hpc-m
Author :
- Esti Hendradi*1
- Tutiek Purwanti*2
- Arycko Andy Suryanto*3
- -*4
- -*5
- Corresponding Author, Department of Pharmaceutics, Faculty of Pharmacy, Airlangga University Jl. Dharmawangsa Dalam, Surabaya 60286 Indonesia
- -
- -
- -
- -
Abstract :
The aimed of this research was to observe the characteristics of dosage form and release of diclofenac sodium with microemulsion w/o system in HPC-M gel base. Diclofenac sodium gel with emulsion was used as comparator. Microemulsion was maked with surfactant (Span 80-Tween 80): cosurfactant (isopropanol) = 4:1. The evaluation included organoleptic, pH, spread diameter measurement of zero load, and also diclofenac sodium release test from gel base of each formula. The result showed that microemulsion system in gel base (formula I) had thicker consistency than emulsion in gel base (formula II). The data was analyzed by statistic program of SPSS using independent sample t-test with degree of confident 95% (α=0.05). The result showed that there was a significant difference between two formulas. Drug release test was carried out with Erweka Dissolution Tester Type DT 820 with apparatus 5 paddle overdisk in phosphate buffer 7.4 ± 0.05, temperature 32°C, 100 rpm. The rate of diclofenac sodium release in formula I was 48.37 ± 1.01 µg/cm2/minute½ and formula II could’t be compared because it’s broken.
Keyword :
diclofenac sodium, microemulsion, drug release, HPC M,
References :
Allen, L. V., Jr., ,(1997) The art and Technology of Pharmaceutical Compounding Washington : American Pharmaceutical Association
Barry, BW,(1983) Dermatological Formulation Percutaneous Absorption New York : Marcel Dekker Inc
Gattefose,(1998) Microemulsion and Cosmetic, France : -
Harwansh, R.K., Rahman, M.A., Dangi, J.S.,(2010) Microemulsion System for Transdermal Delivery of Diclofenac Sodium for Bioavailability Enhancement - : Journal of Pharmacy Research
Idson, B. & Lazarus, J,(1994) Semipadat. In : L. Lachman, H.A. Lieberman, & J.L. Kanig (Eds). Teori dan Praktek Farmasi Industri Jakarta : UI Press
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Volume : 1 / No. : 2 / Pub. : 2012-12 |
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