UNIVERSITAS AIRLANGGA



Detail Article

PharmaScientia

ISSN 2302-0725

Vol. 1 / No. 1 / Published : 2012-07

Order : 2, and page :11 - 15

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Original Article :

Physical characterization and in vitro release study on theophylline-chitosan microparticles (effect on crosslinking time and method of preparation)

Author :

  1. Retno Sari*1
  2. M. Agus Syamsur Rijal*2
  3. Dian Maya Sari*3
  4. Ima Dewi Ruliyana*4
  5. -*5
  1. Corresponding Author, Department of Pharmaceutics, Faculty of Pharmacy, Airlangga University Jl. Dharmawangsa Dalam, Surabaya 60286 Indonesia
  2. Department of Pharmaceutics, Faculty of Pharmacy, Airlangga University Jl. Dharmawangsa Dalam, Surabaya 60286 Indonesia
  3. Department of Pharmaceutics, Faculty of Pharmacy, Airlangga University Jl. Dharmawangsa Dalam, Surabaya 60286 Indonesia
  4. Department of Pharmaceutics, Faculty of Pharmacy, Airlangga University Jl. Dharmawangsa Dalam, Surabaya 60286 Indonesia

Abstract :

Microparticles of theophylline using chitosan as polymer and tripolyphosphate as crosslinker were prepared by ionic gelation (IG) methods. In this study, microparticles were prepared by two different of IG methods : orifice ionic gelation (OIG) and emulsification ionic gelation (EIG) with different crosslinking time. The obtained microparticles were evaluated for its particles size, entrapment efficiency  and in vitro release in CO2 free water. The particle size of microparticles were in the range of 987 – 1687 µm. Microparticles prepared by OIG had larger size than microparticles prepared by EIG and the size grew larger as crosslinking time longer. Both methods with different crosslinking time resulted similar and  relatively high entrapment efficiency (± 60%). The release profile indicated that microparticles prepared by OIG had more retarded release compare to EIG’s particles.. This result will be further studied to decrease the size in nanoparticles range by developing the preparation methods.

Keyword :

microparticle, theophylline, chitosan, ionic gelation,


References :

Swarbrick, J. and Boylan, J.C. ,(1994) Encyclopedia of Pharmaceutical Technology New York : Marcel Dekker Inc.

Birnbaun, D.T. and Peppas, L.B,(2004) Drug Delivery, Cancer Therapy - : -

Sweetman, S.C. ,(0000) Martindale : The Extra Pharmacopoeia - : -

Ko, J.A.,(2002) Preparation and characterization of chitosan microparticle intended for controlled drug delivery - : International Journal of Pharmaceutics

Sinha, V.R.,(2004) Chitosan microspheres as a potential carrier for drug. - : International Journal of Pharmaceutics





Archive Article

Cover Media Content

Volume : 1 / No. : 1 / Pub. : 2012-07
  1. Karakteristik Sediaan Dan Pelepasan Natrium Diklofenak Dalam Sistem Niosom Dengan Basis Gel Carbomer 940
  2. Physical Characterization And In Vitro Release Study On Theophylline-chitosan Microparticles (effect On Crosslinking Time And Method Of Preparation)
  3. Characterisation Of Solid Lipid Nanoparticles P-methoxycinnamic Acid (sln-pmca) Formulated With Different Lipid Component: Stearic Acid And Cetyl Alcohol
  4. Pengaruh Penambahan Manitol Terhadap Pelepasan Ranitidin Hcl Dari Tablet Floating Dengan Hpmc K100m Sebagai Matriks
  5. The Influence Of Niosome System (span 20/60-cholesterol) On The Preparation Characteristics And Released Of Diclofenac Sodium From Gel Carbopol Etd 2020

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