UNIVERSITAS AIRLANGGA



Detail Article

Berkala Ilmiah Kimia Farmasi

ISSN 2302-8270

Vol. 2 / No. 1 / Published : 2013-06

Order : 4, and page :22 - 26

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Original Article :

Pengaruh gugus metoksi posisi orto (o) dan para (p) pada benzaldehida terhadap sintesis turunan khalkon dengan metode kondensasi aldol

Author :

  1. Suzana*1
  2. Melanny Ika. S*2
  3. Kholis Amalia N*3
  4. Juni Ekowati*4
  5. Marcellino Rudyanto*5
  6. Hadi Poerwono *6
  7. Tutuk Budiati*7
  1. Dosen Fakultas Farmasi
  2. Dosen Fakultas Farmasi
  3. Dosen Fakultas Farmasi
  4. Dosen Fakultas Farmasi
  5. Dosen Fakultas Farmasi
  6. Dosen Fakultas Farmasi
  7. Dosen Fakultas Farmasi

Abstract :

The purpose of this research was cognizant of the influence of orto and para methoxy groups on benzaldehyde in synthesis of  2-methoxychalcone and 4-methoxychalcone. Synthesis was done  with aldol condensation using NaOH 50% as catalyst in room temperature for one hour. Orto and para methoxy groups on benzaldehyde had influence by enhancing the reactivity C carbonyl benzaldehyde, that build the carbonyl positive center faster.  Chalcone was determined as yellow crystal (66,4%), melting point 53-54 oC, 2-methoxychalcone was yellow crystal (75,9%), m.p. 58-59oC, and yield of 4-methoxychalcone was 85,2%, m.p. 73-74 oC. Compounds identification using UV-Vis, Infrared and 1H-NMR spectroscopy.      

Keyword :

Synthesis, methoxy groups, aldol condensation, chalcone derivatives,


References :

Jayapal, MR.; Prasad, K.S. and Sreedhar, N.Y. ,(2010) Synthesis and Characterization of 2,6-Dihydroxy Substituted Chalcones Using PEG-400 as a Recyclable Solvent Journal : J. Pharm. Sci. & Res. Vol.2 (8)

Silverstein RM., Webster FX., Kiemle DJ.,(2005) Spectromeric Identification of Organic Compound New York : John Willey and Sons Inc





Archive Article

Cover Media Content

Volume : 2 / No. : 1 / Pub. : 2013-06
  1. Validasi spektrofotometri visible untuk penentuan kadar formalin dalam daging ayam
  2. Validasi metode kromatografi gas-spektrometri massa untuk penetapan kadar residu endosulfan dalam kubis
  3. Sintesis dan uji aktivitas antikanker senyawa 1-(2-klorobenzoiloksi)urea dan 1-(4-klorobenzoiloksi)urea
  4. Pengaruh gugus metoksi posisi orto (o) dan para (p) pada benzaldehida terhadap sintesis turunan khalkon dengan metode kondensasi aldol
  5. Modifikasi struktur n-fenilurea menjadi senyawa baru n-benzoilfenilurea dan 4-fluorobenzoilfenilurea serta uji aktivitasnya sebagai penekan susunan saraf pusat
  6. Aktivitas antinociceptiv dan uji in silico terhadap cyclooxygenase dari asam p-metoksisinamat dan asam m-metoksisinamat
  7. Docking dan modifikasi struktur senyawa baru turunan parasetamol

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