UNIVERSITAS AIRLANGGA



Detail Article

Indonesian Journal of Clinical Pathology and Medical Laboratory

ISSN 0854-4263

Vol. 16 / No. 1 / Published : 2009-11

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Original Article :

Cd4 analysis in treatment of hiv-tb co-infected patients

Author :

  1. Nursin Abd. Kadir*1
  2. Nurhayana Sennang*2
  3. Hardjoeno*3
  1. Departemen Patologi Klinik, Fakultas Kedokteran Universitas Hasanuddin RS Dr. Wahidin Sudirohusodo Makassar
  2. Departemen Patologi Kinik FK - UNHAS - RS. Dr. Wahidin Sudirohusodo Jl. Perintis Kemerdekaan Km 10 Talamarea Makassar
  3. Departemen Patologi Kinik FK - UNHAS - RS. Dr. Wahidin Sudirohusodo Jl. Perintis Kemerdekaan Km 10 Talamarea Makassar

Abstract :

The Human Immunodeficiency Virus (HIV) epidemic has increased the burden of tuberculosis (TB) among young adults, especially in populations where the prevalence of TB infection is high like Indonesia. TB is the most common opportunistic infection on HIV patients (50%) in developing countries. CD4 also known as T helper lymphocytes are coordinators of body`s immune response, and it has been declining in HIV infection and be worsened by TB infection. CD4 count are standard laboratory marker of disease progression to follow-up and prognosis antiretroviral therapy in HIV infection. Aims to see the value of CD4 count of HIV-TB co-infected patients before and after antituberculosis together with antiretroviral therapy. A longitudinal study was conducted by collecting secondary data from the medical record and the results of Clinical Pathology Laboratory of HIV-TB co-infected patients at Wahidin Sudirohusodo Hospital period July 2007–August 2008. Data were analyzed by Wilcoxon Signed Rank Test and Mann Whitney Test with a = 0.05. Total samples (n) were 20 patients (14 patients with continous therapy and 6 uncontinous therapy). We found different means between CD4 count before and after Therapy. CD4 count before therapy was 71.15 ± 81.04 and after therapy was 114.95 ± 109.71 (p = 0.089) with Wilcoxon Signed Rank Test. The analyzed were continued by divided samples in continous group compared with uncontinous group therapy. The result showed the CD4 alteration in continous group was 853.8% and uncontinous group was -56.6% where p = 0.000 (Mann Whitney test). CD4 count has increased significantly in HIV-TB co-infected patients 8.5 fold from CD4 baseline with continous therapy and the uncontinous one has decreased 0.5 fold from CD4 baseline.

Keyword :

HIV-TB Co-infected patients, CD4 count, continous therapy, uncontinous therapy,


References :

Sharma SK, Mohan A, Kadhiravan T,(2005) HIV-TB Coinfection India : Indian J res





Archive Article

Cover Media Content

Volume : 16 / No. : 1 / Pub. : 2009-11
  1. Homolog legionella pneumophila distribution and nosocomial pneumopniae
  2. Diagnostic value of malaria antigen cassette on malaria disease
  3. Cd4 analysis in treatment of hiv-tb co-infected patients
  4. Analysis of uric acid level in patients of carcinoma mammae
  5. Anti hcv and the patient’s prevalence of virus hepatitis c infection
  6. The evaluation of transaminase activities, and bilirubin level in patients with hepatitis b virus and c virus
  7. Correlation degree of non-alcoholic fatty liver with aminotransferase serum activity
  8. Accuracy of bactident aminopeptidase test in identification gram negative bactery)
  9. Study of cd38 expression on lymphocyte 8+, cd4+ profile, and clinical state immunological and clinical state profile of aids/hiv patients with antiretroviral therapy)
  10. Eosinofil after mucosal nasal brushing and routine hematology in allergy rhinitis
  11. Normoblast counting between acute myeloblast leukemia and acute lymphoblastic leukemia in peripheral blood smear of patients
  12. Measurement and clinical application of thrombin activatable fibrinolysis inhibitor
  13. Abnormal trombosit in post-partum
  14. Laboratory costing per test based on jaros ml method

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