UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 42 / No. 2 / Published : 2006-04

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Original Article :

Balancing selection of hla class ii among indonesians

Author :

  1. Joewono Soeroso*1
  1. Department of Internal Medicine Airlangga University School of Medicine Dr Soetomo Teaching Hospital Surabaya, Indonesia

Abstract :

Polymorphisms of HLA-DRB1* and HLA-DQB1* in rheumatoid arthritis (RA) is model of multiple exposure of HLAclass II towards abundant exogenous antigen. This can be the evidence of balancing selection in molecular evolution, particularly for HLA class II. The objectives of this study was to determine the frequencies of homozygosity of HLADRB1* and HLA-DQB1* in patients with RA, in order to estimate balancing selection. Genomic DNA of 89 RA cases (ACR Criteria 1987) from 6 hospitals in Java and Bali, and 93 healthy controls were analyzed for HLA-DRB1* through PCR-SSO. Descriptive statistics were used. The results of this study showed lower frequencies of HLA-DRB1*, lower HLA-DRB1* homozygosities (e.g. 2.2%), HLA-DRB1*04 in RA cases, 0% in controls. It can be concluded that lower frequencies of HLA-DRB1* homozygous reveals that balancing selection may exist in Indonesian population.

Keyword :

HLA- class II, homozygosity, balancing selection,


References :

S Albani,(1996) A multistep molecular mimicry hypothesis for the pathogenesis of rheumatoid arthritis no info : Immunology Today

DA Carson,(1996) A multistep molecular mimicry hypothesis for the pathogenesis of rheumatoid arthritis no info : Immunology Today

FC Arnett,(1988) The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis no info : Arthritis Rheum

SM Edworthy,(1988) The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis no info : Arthritis Rheum

DA Bloch,(1988) The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis no info : Arthritis Rheum

EHA Choy,(2001) Mechanisms of Disease: Cytokine pathways and joint inflammation in rheumatoid arthritis no info : N Engl J Med

GS Panayi,(2001) Mechanisms of Disease: Cytokine pathways and joint inflammation in rheumatoid arthritis no info : N Engl J Med



Archive Article

Cover Media Content

Volume : 42 / No. : 2 / Pub. : 2006-04
  1. Balancing Selection Of Hla Class Ii Among Indonesians
  2. The Influence Of Extremely Low Frequency (elf) Magnetic Fields Induction To The Production Of Ifn- γ On Balb/c Mice
  3. Comparison Of Serum Estrogen And Plasma Transforming Growth Factor Β-1 (tgf Β-1) Levels In Benign Prostatic Hyperplasia (bph)–non Bph Patients Over 50 Years Old And Younger (30-40 Years Old)
  4. Role Of Mouthpiece On The Efficacy And Safety Of Budesonide Turbuhaler In The Treatment Of Asthmatic Children: Lesson From M3 Study
  5. The Effect Of Kegel On Management Of Urine Elimination Problems For Elderly A Quasy–experimental Study
  6. Prevalence Of Cataract In Diabetic Patients At Ophthalmology Outpatient Clinic, Dr Soetomo Hospital, Surabaya
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  10. Ocular Complication Of Ethambutol Used For Pulmonary Tuberculosis Therapy In Balai Pengobatan Dan Pemberantasan Penyakit Paru, Surabaya
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