UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 48 / No. 2 / Published : 2012-04

Order : 3, and page :54 - 57

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Original Article :

Soot particulate exposure increases cd54/intercellular adhesion molecule-1 (icam-1) expression in cardiovascular disorder

Author :

  1. Meity Ardiana*1
  2. M. Aminuddin*2
  1. Dosen Fakultas Kedokteran
  2. Dosen Fakultas Kedokteran

Abstract :

Exposure of air pollution has become a risk factor for cardiovascular disease. One mechanism thought to contribute is oxidative stress, which will increase the reactive oxygen species resulting in release of pro-inflammatory cytokines and increased expression of adhesion molecules such as intercellular adhesion molecule-1 (ICAM-1). The aim of this study was to describe the effects of soot particulate (carbon black powder) exposures on ICAM-1 expressions in mechanism of cardiovascular disorders. Experiments were performed on white female rats (Rattus novergicus) divided into 3 groups: control group (P0) (n=12), without exposure to soot particulate; an treatment group 1 (P1) (n=12), exposed to soot particulate concentration of 532 mg/m3 one hour/day for 30 days; and an treatment group 2 (P2) (n=12), exposed to soot particulate concentration of 1064 mg/m3 one hour/day for 30 days. Immunohistochemical staining was used to quantify the expression of ICAM-1 in cardiac tissues. We quantified the expressions of ICAM-1 with the number of immunoreactive cells in 5 fields of view. The mean ICAM-1 expressions were different between P0, P1 and P2 (4.9, 21.47, 36.33). Expression of ICAM-1 was statistically significant between three groups (p=0,001). The increase ofICAM-1 expression in P0 compared to P1 (p=0,019), P0 compared to P2(p=0,000) and P1 compared to P2 (p=0.045) were significant. Exposures to soot particulate matter increased the ICAM-1 expression in subjects significantly. Our findings suggest a key role of activation inflammatory pathway in response to soot particulate exposure in cardiovascular disease.

Keyword :

soot particulate, cardiovascular disorders, oxidative stress, ICAM-1,


References :

Bind MA, Baccarelli A, Zanobetti A, Tarantini L, Suh H, Vokonas P, Schwartz J,(2012) Air pollution and markers of coagulation, inflammation, and endothelial function: associations and epigene-environment interactions in an elderly cohort - : Epidemiology

Alfaro-Moreno E, Garcia-Cuellar C, De-Vizcaya-Ruiz A, Rojas-Bracho L, Osornio-Vargas AR,(2010) Cellular mechanisms behind particulate matter air pollution-related health effects. In: Gurjar BR, Molina LT, Ojha CSP (eds). Air Pollution Health and Environmental Impacts Boca Raton : CRC Press





Archive Article

Cover Media Content

Volume : 48 / No. : 2 / Pub. : 2012-04
  1. Blood glucose reduction in mice (mus musculus) resulting from the administration of pare (momordica charantia) fruit flesh juice
  2. Effect of reprocessing cellulose dialyzer substituted with the product r-hydrogen peroxide to clearance urea dialyzer in chronic hemodialysis patient
  3. Soot particulate exposure increases cd54/intercellular adhesion molecule-1 (icam-1) expression in cardiovascular disorder
  4. Red yeast rice (monascus purpureus) extract increases interleukin-2 level in dengue infection patients
  5. Effects of zinc on different nutrition improvement status in hiv/aids patient
  6. The intestinal cryptosporidiosis in hiv/aids patients who have homosexual behaviour
  7. Characteristics of hiv-positive pregnant women in dr. soetomo hospital, surabaya
  8. Personality affects depression occurrence in hiv/aids patient
  9. Heating therapy lowers blood glucose level in mice (mus musculus)

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