UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 41 / No. 3 / Published : 2005-07

Order : 3, and page :190 - 194

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Original Article :

The potency of piperine as antiinflammatory and analgesic in rats and mice

Author :

  1. Sri Agus Sudjarwo*1
  1. Department of Pharmacology Airlangga University School of Medicine Surabaya

Abstract :

The potency of piperine as anti inflammatory and analgesic were investigated. Piperine was evaluated for antiinflammatory effect by carrageen-induced rat paw edema. Sprague Dawley Rats were divided into the control groups were given saline perorally, piperine groups received doses of 2.5; 5 and 10 mg/kg piperine (peroral) respectively. This was followed by the administration of 1 % caragenin through the intraplantar route 30 min after administration piperine or saline. After the carrageenan injection was measurement of paw volume and prostaglandin production. The piperine in doses of 2.5; 5 and 10 mg/kg showed 5.4; 43.8 and 54.8 % inhibition of paw edema respectively at the end of three hours. The increase in prostaglandin (PGE2) levels after carrageenan injection was significantly prevented by preadministration of the piperine at 5 and 10 mg/kg but not piperine at 2.5 mg/kg. These results suggest that piperine has antiinflammatory properties may be attributed to inhibition of prostaglandin release. The analgesic activity of piperine was tested by acetic acid-induced writhing response and hot plate method in albino mice. The piperine in doses of 2.5; 5 and 10 mg/kg showed the percentage of protection from writhing was 1.4; 5.9 and 3.3 % respectively. However the piperine at 2.5; 5 and 10 mg/kg resulted no significantly analgesic effect in acetic acid-induced writhing response. In the hot plate model, the piperine at 2.5; 5 and 10 mg/kg resulted no significantly analgesic effect after 30 min, 1, 2 and 3 h of administration. These results suggest that piperine has not analgesic properties.

Keyword :

Writhing test, hot plate, carrageen, prostaglandin,


References :

Carter RB,(1991) Differentiating analgesic and nonanalgesic drug activities on rat hotplate: Effect of behavioral end-point - : Pain

Collier HDJ, Dinnin LC, Johnson CA, Schneider C,(1968) The abdominal responseand its suppression by analgesic drugs in the mouse - : Br J Pharmacol





Archive Article

Cover Media Content

Volume : 41 / No. : 3 / Pub. : 2005-07
  1. Editorial Vol 41 No 3 2005
  2. Opinion: The Dramatic Avian Influenza Epidemic And The Pig Connection
  3. The Potency Of Piperine As Antiinflammatory And Analgesic In Rats And Mice
  4. Brain Derived Neurotrophic Factor (bdnf) Is A Key Mediator Of Learning Plasticity
  5. Migraine Headache In A Child With House Dust And Mite Allergy. A Case Report
  6. Long Versus Standard Initial Steroid Therapy For Children With Idiopathic Nephrotic Syndrome
  7. Research Article: The Effect Of Nursing Care Approach Model (ncam = Pakar) On The Increase Of Cd4 Cell Count For Patient With Hiv Infection
  8. Clinical Outcome Of Asthma With House Dust Immunotherapy In Children
  9. Different Clinical Manifestation Of Cerebral Lupus Due To Different Brain Involvement. A Report Of Two Cases
  10. A Comparative Test Of Eyedrops Timolol 0.5% And Betaxolol 0.5% In The Reduction Of Intraocular Pressure In Primary Open-angle Glaucoma In Dr Soetomo Hospital, Surabaya
  11. Efficacy Of Fine Needle Biopsy In The Diagnosis Of Tuberculous Cervical Lymphadenitis
  12. Molecular And Immunological Aspects Of Anemia In Malaria
  13. Review Article And Clinical Experience: Insulin Glargine Combined With Oral Agent In T2dm (clinical Uses Of Formulas: 1/3, 5-5, 2-2, 1-1, And 1-2)