UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 48 / No. 2 / Published : 2012-04

Order : 4, and page :58 - 66

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Original Article :

Red yeast rice (monascus purpureus) extract increases interleukin-2 level in dengue infection patients

Author :

  1. Anita Rahmadani Adnan*1
  2. Suharto*2
  3. Erwin Astha Triyono*3
  1. Dosen Fakultas Kedokteran
  2. Dosen Fakultas Kedokteran
  3. Dosen Fakultas Kedokteran

Abstract :

Thrombocytopenia is one of the main clinical manifestations and key components in Dengue infection. Preclinical research has shown that the extract of red yeast rice (Monascus purpureus) can increase platelet count. However the mechanism has not been understood. It has been suggested that the mechanisms are due to anti-inflammatory effect and increase of thrombopoiesis. The aim of this study was to investigate the effect of Monascus purpureus extract on increasing thrombopoiesis, we examined its effect on IL-3 level as one of the hematopoietic growth factor in patients with Dengue infection. This randomized controlled trial compare Dengue patients who received Monascus purpureus extract with Dengue patients in the control group. Complete blood count and IL-3 level were evaluated at enrollment and after administration of Monascus purpureus extract. Among 15 patients who received Monascus purpureus and 15 patients in control group, there are increase of IL-3 level 0,59 ± 8,72 pg/mL in Monascus purpureus group, and 0,25 ± 6,67 pg/mL in control group. Monascus purpureus group had higher increase of IL-3 level but statistically not significant (p = 0,91). In conclusion, Monascus purpureus extract increased IL-3 level in patients with Dengue infection compared to control group which was statistically not significant. (FMI 2012;48:58-66)

Keyword :

Dengue infection, IL-3 , Monascus purpureus,


References :

Gomber S, Ramachandran VG, Kumar S, Agarwal KN, Gupta P, Gupta P, Dewan DK,(2001) Hematological observations as diagnostic markers in dengue hemorrhagic fever-a reappraisal - : Indian Pediatr

Díaz-Quijano FA, Villar-Centeno LA, Martínez-Vega RA,(2006) Complications associated to severe thrombocytopenia in patients with dengue - : Rev Med Chil





Archive Article

Cover Media Content

Volume : 48 / No. : 2 / Pub. : 2012-04
  1. Blood Glucose Reduction In Mice (mus Musculus) Resulting From The Administration Of Pare (momordica Charantia) Fruit Flesh Juice
  2. Effect Of Reprocessing Cellulose Dialyzer Substituted With The Product R-hydrogen Peroxide To Clearance Urea Dialyzer In Chronic Hemodialysis Patient
  3. Soot Particulate Exposure Increases Cd54/intercellular Adhesion Molecule-1 (icam-1) Expression In Cardiovascular Disorder
  4. Red Yeast Rice (monascus Purpureus) Extract Increases Interleukin-2 Level In Dengue Infection Patients
  5. Effects Of Zinc On Different Nutrition Improvement Status In Hiv/aids Patient
  6. The Intestinal Cryptosporidiosis In Hiv/aids Patients Who Have Homosexual Behaviour
  7. Characteristics Of Hiv-positive Pregnant Women In Dr. Soetomo Hospital, Surabaya
  8. Personality Affects Depression Occurrence In Hiv/aids Patient
  9. Heating Therapy Lowers Blood Glucose Level In Mice (mus Musculus)

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