UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 47 / No. 4 / Published : 2011-10

Order : 4, and page :215 - 218

Related with : Scholar   Yahoo!   Bing

Original Article :

Liver involvement in children with dengue infection

Author :

  1. Bagus Setyoboedi *1
  2. Dina Angelika*2
  3. Enny Zuraida*3
  4. Widodo Darmowandowo *4
  5. Sjamsul Arief*5
  1. Division of Hepatology, Department of Child Health, Faculty of Medicine, Airlangga University
  2. Division of Hepatology, Department of Child Health, Faculty of Medicine, Airlangga University
  3. Division of Hepatology, Department of Child Health, Faculty of Medicine, Airlangga University
  4. Division of Infectious Disease and Tropical Pediatric Department of Child Health, Faculty of Medicine, Airlangga University
  5. Division of Hepatology, Department of Child Health, Faculty of Medicine, Airlangga University

Abstract :

Liver is not the major target organ of dengue virus, otherwise hepatic dysfunction has been reported in adult patient with dengue infection. Only a few cases of liver involvement in children with dengue infection have been explored. This study was to investigate manifestations of liver involvement in children with dengue infection. This was a case-control study was conducted at dr. Soetomo Hospital from March 2008 to April 2009. Subjects were children who suffered from dengue virus infection due to clinical diagnosis based on WHO criteria. Data was taken from medical record. Variables analyzed consisted of age, sex, clinical manifestations including hepatomegaly, jaundice, hepatic encephalopathy, and circulatory failure; laboratory findings including serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT). The data was analyzed using chi-square and t-test with 95% confidence interval. We found that from 72 patients, 34 patients had hepatomegaly, 4 patients had hepatic encephalopathy, and 52 patients with elevated serum transaminases level. There were significant differences in elevated AST level (mean difference 28.5 [9.4 to 47.5], p 0.004) and hepatomegaly (proportion difference 0.3 [0.1 to 0.5], p 0.018) related to the severity. Elevated ALT level >3 fold (PR 4.1, 1.4-11.9, p 0.008) and hepatomegaly (PR 3.5, 1.2-10.1, p 0.018) associated with circulatory failure. In conclusion, manifestations of liver involvement in children with dengue infection in this study were hepatomegaly, elevated serum transaminases level, and hepatic encephalopathy. Elevated ALT level >3 fold and hepatomegaly associated with circulatory failure.

Keyword :

children, dengue infection, liver involvement,


References :

Kumar R, Tripathi P.,(2008) Prevalence of dengue infection in north Indian children with acute hepatic failure - : Ann of Hepatology

Fadilah S, Abdul S, Sanusi S,(2000) A comparison of the pattern of liver involvement in dengue hemorrhagic fever with classic dengue fever - : Southeast Asian J Trop Med Pub Health

Gulati S, Maheshwari A.,(2007) Atypical manifestations of dengue - : Trop Med Int Health

Itha S, Kashya R,(2005) Profile of liver involvement in dengue virus infection - : Natl Med J India

Dhooria G,(2008) Clinical profile and outcome in children of dengue hemorrhagic fever in north india - : Iran J Pedatr





Archive Article

Cover Media Content

Volume : 47 / No. : 4 / Pub. : 2011-10
  1. Antibiotic Resistance Control Program (arcp) Improving Antibiotic Use In Pediatric Hematology And Oncology Patients At Dr Soetomo Hospital In 2006 And 2008
  2. Sensitivity And Specificity Of Clinical Features Of Influenza Like Illness And Laboratorical Findings For Diagnosed Influenza A (h1n1) In Children
  3. Risk Factors For Birth Asphyxia
  4. Liver Involvement In Children With Dengue Infection
  5. Mechanical Ventilation Vs Nasal Cpap Duration And The Risk Of Late Onset Sepsis In Premature Babies With Respiratory Distress Syndrome
  6. Nucleic Acid Amplification Of The Rpob Region Of Mycobacterium Tuberculosis In Pulmonary Tuberculosis Diagnosis
  7. Effect Of Oral-estrogen Conjugate On B-lymphocyte Proliferation In The Peyer’s Patches Of Adult Female Balb/c Mice Ileum
  8. The Effect Of Emotional Quality Management On Stress, And Optimism In Women With Breast Cancer
  9. Quality And Efficiency Improvement Of Professional Medical Doctor Education In Public Health Field Using Objective Structured Public Health Examination (osphe) Approach At Faculty Of Medicine Airlangga University
  10. Review Article: Role Of Ve-cadherin In Vascular Permeability Regulation
  11. Depth Of Human Hypophysial Fossa Due To Aging Process: A Morphologic Research

Information FMI