UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 47 / No. 4 / Published : 2011-10

Order : 10, and page :248 - 251

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Original Article :

Review article: role of ve-cadherin in vascular permeability regulation

Author :

  1. Ira Dharmawati*1
  1. Department of Child Health, Airlangga University Faculty of Medicine

Abstract :

Endothelial permeability is regulated partly by cells adheren junctions (AJs), which opens and closes with the dynamic. In endothelial cells, AJs largely composed of vascular endothelial cadherin (VE-cadherin), cadherin family member that is a specific adhesion protein only in endothelial cells, through the cytoplasm domain binds to other proteins, including p120, catenin-β - and plakoglobin. In many ways the endogenous pathway increases vascular permeability by affecting the function and organization of VE-cadherin and other proteins at AJs. We will discuss some of the factors that can increase vascular permeability, including vascular endothelial growth factor (VEGF), induced tyrosine phosphorylation of VE-cadherin, which accompanies an increase in vascular permeability and leukocyte diapedesis, in addition, the internalization of VE-cadherin and splits can cause AJS being dismantled. Possible use of inhibitors of the SRC and other kinases, of agents that increase cAMP levels, and lytic enzyme inhibitors as pharmacological tools are to reduce endothelial permeability.

Keyword :

permeability, VE-cadherin, adherens junctions, endothelial cells,


References :

Gavard, J. and J. S. Gutkind,(2006) VEGF controls endothelial-cell permeability by promoting the beta-arrestin-dependent endocytosis of VE-cadherin - : Nat Cell Biol

Lee, W. L. and A. S. Slutsky,(2010) Sepsis and endothelial permeability - : N Engl J Med

Mehta, D. and A. B. Malik,(2006) Signaling mechanisms regulating endothelial permeability - : Physiol Rev

Vestweber, D,(2008) VE-cadherin: the major endothelial adhesion molecule controlling cellular junctions and blood vessel formation - : Arterioscler Thromb Vasc Biol

Allingham, M. J., J. D. van Buul, et al. ,(2007) ICAM-1-mediated, Src- and Pyk2-dependent vascular endothelial cadherin tyrosine phosphorylation is required for leukocyte transendothelial migration - : J Immunol





Archive Article

Cover Media Content

Volume : 47 / No. : 4 / Pub. : 2011-10
  1. Antibiotic Resistance Control Program (arcp) Improving Antibiotic Use In Pediatric Hematology And Oncology Patients At Dr Soetomo Hospital In 2006 And 2008
  2. Sensitivity And Specificity Of Clinical Features Of Influenza Like Illness And Laboratorical Findings For Diagnosed Influenza A (h1n1) In Children
  3. Risk Factors For Birth Asphyxia
  4. Liver Involvement In Children With Dengue Infection
  5. Mechanical Ventilation Vs Nasal Cpap Duration And The Risk Of Late Onset Sepsis In Premature Babies With Respiratory Distress Syndrome
  6. Nucleic Acid Amplification Of The Rpob Region Of Mycobacterium Tuberculosis In Pulmonary Tuberculosis Diagnosis
  7. Effect Of Oral-estrogen Conjugate On B-lymphocyte Proliferation In The Peyer’s Patches Of Adult Female Balb/c Mice Ileum
  8. The Effect Of Emotional Quality Management On Stress, And Optimism In Women With Breast Cancer
  9. Quality And Efficiency Improvement Of Professional Medical Doctor Education In Public Health Field Using Objective Structured Public Health Examination (osphe) Approach At Faculty Of Medicine Airlangga University
  10. Review Article: Role Of Ve-cadherin In Vascular Permeability Regulation
  11. Depth Of Human Hypophysial Fossa Due To Aging Process: A Morphologic Research

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