Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 39 / No. 1 / Published : 2003-01

Order : 11, and page :49 - 53

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Original Article :

Thrombocytopenia in patients with tetralogy of fallot, a condition requiring immediate attention

Author :

  1. Teddy Ontoseno*1
  1. Division of Cardiology Department of Pediatrics Airlangga University School of Medicine Dr Soetomo Teaching Hospital, Surabaya

Abstract :

Background: In Indonesia, most of the patients (95%) with Tetralogy of Fallot (TF) are still faced to disadvantageous situation, since it remains difficult for them to obtain immediate surgical corrective procedure. Delayed surgical procedure for these patients may often lead to the occurrence of fatal complications, i.e., hemostatic function disorder and cerebrovascular accident accompanied with thrombocytopenia. Objective: to prove the influence of arterial oxygen saturation on the development of thrombocytopenia and to disclose correlation between arterial oxygen saturation and cut-off point and thrombocytopenia in TF patients. Methods: This was a case control study undertaken by involving 94 patients with Tetralogy of Fallot. Patients without thrombocytopenia were assigned as control group, while those with thrombocytopenia belonged to case group. Thrombocytopenia was determined as having 33,000 - 135,000 cells/mm3 cell dynamic. Arterial oxygen saturation was below 90% in room temperature, as measured by pulse oximetri. Multiple logistic regression analysis, Kappa association analysis, and McNemar test were employed in this study. Results: From 47 patients studied, significant difference was found between age and thrombocytopenic development. Average age of thrombocytopenic group was 58.81 months, and non-thrombocytopenic group was 36.19 months. Oxygen saturation of <60% was found significantly influencing the development of thrombocytopenia. Cut-off point of arterial oxygen saturation was 57% (Kappa 9.09505 and p < 0.05). Conclusions: (1) arterial oxygen saturation influences thrombocytopenic development; (2) a negative correlation of 0.2093 exists between arterial oxygen saturation and thrombocytopenic development; (3) cut-off point of arterial oxygen saturation is 57% with sensitivity and specificity of respectively 100% and 93.6%.

Keyword :

Tetralogy of Fallot, thrombocytopenia,

References :

Anderson RH, McCarthey FJ, Shinebourne EA, Tunan M,(1997) Pediatric Cardiology, Vol 2 London : Churchill Livingstone

Athens JW,(1993) Polycythemia: Erythrocytosis. In (G Richard Lee, ed) Wintrobe's Clinical Hematology, 9th edition Philadelphia : Lee and Febiger

Archive Article

Cover Media Content

Volume : 39 / No. : 1 / Pub. : 2003-01
  1. Editorial Vol 39 No 1 2003
  2. Opinion: Problem Based Learning And The Change Of Academic Behaviour
  3. Population Data On The Locus D16s83 Of Vntr (variable Number Of Tandem Repeat) Polymorphism In The Population Around Surabaya, East Java, Indonesia
  4. An Immunohistochemical Analysis Of Tgf-ß1, As A Predictor Of Delayed Wound Healing In Episiotomy Surgery Of Sprague Dawley Rats
  5. Age At Menarche In Indonesia
  6. Optimizing Children's Emotional Quotient By Monday-thursday Fasting
  7. The Widal Slide Agglutination Test (sat) Using Antigen From Locally Prevalent Salmonella Typhi As A Diagnostic Tool For Typhoid Fever
  8. Cytokine Profiles Of Typhoid Patients Hospitalized At Communicable Disease Wards, Dr Soetomo Hospital, Surabaya
  9. Stimulatory Effect Of Bradykinin On The Activity Of Cyclooxygenase And Prostaglandin Production In Culture Fibroblasts
  10. Stress Proteins And Sirs-sepsis The Possible Roles Of Heat Shock Proteins (hsp’s) In The Development Of Systemic Inflammatory Response Syndrome (sirs)
  11. Thrombocytopenia In Patients With Tetralogy Of Fallot, A Condition Requiring Immediate Attention
  12. Concurrent Dengue Infection And Enteric Fever. A Case Series
  13. Review Article And Clinical Experience: Recent Advances In The Treatment Of Osteoporosis (the Roles Of New Bisphosphonate)
  14. Using Conjunctival Flap For The Replacement Of Jone’s Tube In Conjunctivodacryocystorhinostomy (cdcr)